Abstract
Human monocytes displayed increased expression of CD40 following infection with virulent Mycobacterium tuberculosis. Nevertheless, soluble CD40 ligand (CD40L; also designated CD154) had no effect on the intracellular growth of the organism. Restriction of the intracellular growth of M. tuberculosis by peripheral blood lymphocytes and antigen-specific CD4+ T-cell lines likewise was not reduced by blocking anti-CD40L monoclonal antibody 5c8.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Antibodies, Monoclonal / immunology
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CD4-Positive T-Lymphocytes / cytology
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CD4-Positive T-Lymphocytes / immunology
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CD40 Antigens / biosynthesis
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CD40 Antigens / immunology
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CD40 Ligand / immunology*
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CD40 Ligand / pharmacology
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Cell Line
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Humans
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Intracellular Fluid / microbiology
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Lymphocytes / cytology
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Lymphocytes / immunology
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Lymphocytes / microbiology
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Middle Aged
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Monocytes / immunology
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Monocytes / microbiology
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Mycobacterium tuberculosis / growth & development
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Mycobacterium tuberculosis / immunology*
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Recombinant Proteins / immunology
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Recombinant Proteins / pharmacology
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Virulence
Substances
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Antibodies, Monoclonal
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CD40 Antigens
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Recombinant Proteins
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CD40 Ligand