The venometer is a nurse- or technician-operated machine that uses automated strain gauge plethysmography to detect deep vein thrombosis (DVT). We compared the venometer with contrast venography to determine its accuracy, and also used it to triage patients between admission with subsequent anticoagulation and out-patient investigation without anticoagulation. We enrolled 307 consecutive patients presenting to the medical admissions unit with suspected DVT, of whom 270 underwent both plethysmography and venography. Plethysmography produced a negative predictive value (NPV) of 97% and a sensitivity of 90% for proximal DVT. It also produced a false negative rate of 10% for proximal DVT, For distal DVT, sensitivity was 66%, specificity 80%, positive predictive value 36% and NPV 93%. We conclude that the automated venometer report is a quick, non-invasive and easy to use initial screening test. However, it is not sufficiently accurate in a medical admissions unit to be a definitive diagnostic test for DVT and may, therefore, be best used in combination with clinical risk assessment and D-dimer assay with more definitive radiological investigations as necessary.