Abstract
'RNA silencing' is the suppression of gene expression through nucleotide sequence-specific interactions that are mediated by RNA. Initially identified as an immune system that is targeted against transposons and viruses, RNA silencing is emerging as a fundamental regulatory process that is likely to affect many layers of endogenous gene expression in most, if not all, eukaryotes.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Caenorhabditis elegans / genetics
-
Gene Silencing*
-
Humans
-
MicroRNAs / genetics
-
MicroRNAs / metabolism*
-
RNA Processing, Post-Transcriptional
-
RNA, Small Interfering / genetics
-
RNA, Small Interfering / metabolism*
-
Signal Transduction
-
Substrate Specificity
-
Transcription, Genetic / genetics*
Substances
-
MicroRNAs
-
RNA, Small Interfering