Observation of intermittency in gene expression on cDNA microarrays

Leif E Peterson; Kwong Lau

doi:10.1186/gb-2002-3-7-preprint0005

Observation of intermittency in gene expression on cDNA microarrays

Genome Biol. 2002 May 29;3(7):PREPRINT0005. doi: 10.1186/gb-2002-3-7-preprint0005. Epub 2002 May 29.

Authors

Leif E Peterson¹, Kwong Lau

Affiliation

¹ Departments of Medicine, Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA. peterson@bcm.tmc.edu

PMID: 12184800
DOI: 10.1186/gb-2002-3-7-preprint0005

Abstract

We used scaled factorial moments to search for intermittency in the log expression ratios (LERs) for thousands of genes spotted on cDNA microarrays (gene chips). Results indicate varying levels of intermittency in gene expression. The observation of intermittency in the data analyzed provides a complimentary handle on moderately expressed genes, generally not tackled by conventional techniques.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Gene Expression Profiling / methods*
Gene Expression Profiling / statistics & numerical data
Gene Expression Regulation / genetics
Models, Genetic
Oligonucleotide Array Sequence Analysis / methods*
Oligonucleotide Array Sequence Analysis / statistics & numerical data