Abstract
In Drosophila, the development of the compound eye depends on the movement of a morphogenetic furrow (MF) from the posterior (P) to the anterior (A) of the eye imaginal disc. We define several subdomains along the A-P axis of the eye disc that express distinct combinations of transcription factors. One subdomain, anterior to the MF, expresses two homeobox genes, eyeless (ey) and homothorax (hth), and the zinc-finger gene teashirt (tsh). We provide evidence that this combination of transcription factors may function as a complex and that it plays at least two roles in eye development: it blocks the expression of later-acting transcription factors in the eye development cascade, and it promotes cell proliferation. A key step in the transition from an immature proliferative state to a committed state in eye development is the repression of hth by the BMP-4 homolog Decapentaplegic (Dpp).
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Animals, Genetically Modified
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Basic Helix-Loop-Helix Transcription Factors
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DNA-Binding Proteins / genetics
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Drosophila / genetics*
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Drosophila / growth & development*
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Drosophila Proteins / genetics
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Eye / growth & development*
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Eye Proteins / genetics
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Gene Expression Regulation, Developmental
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Genes, Homeobox*
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Genes, Insect*
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Homeodomain Proteins / genetics
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Insect Proteins / genetics
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Lac Operon
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Nuclear Proteins / genetics
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Repressor Proteins / genetics
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Transcription Factors / genetics
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Zinc Fingers / genetics
Substances
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Basic Helix-Loop-Helix Transcription Factors
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DNA-Binding Proteins
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Drosophila Proteins
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Eye Proteins
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Homeodomain Proteins
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Insect Proteins
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Nuclear Proteins
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Repressor Proteins
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Transcription Factors
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dac protein, Drosophila
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dpp protein, Drosophila
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ey protein, Drosophila
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eya protein, Drosophila
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hairy protein, Drosophila
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hth protein, Drosophila
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hairy protein, insect
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tsh protein, Drosophila