Fluorescence-enhanced, near infrared diagnostic imaging with contrast agents

Curr Opin Chem Biol. 2002 Oct;6(5):642-50. doi: 10.1016/s1367-5931(02)00356-3.

Abstract

The deep tissue propagation of near-infrared (NIR) light between 700-900 nm offers new opportunities for diagnostic imaging when employing sensitive detection techniques and NIR excitable fluorescent agents that target and report disease and metabolism. Herein, we highlight approaches for illuminating tissues and monitoring the re-emitted fluorescence for tomographic reconstruction, strategies for developing fluorescent dye constructs, and clinical opportunities for fluorescence-enhanced NIR optical imaging.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Contrast Media*
  • Fluorescent Dyes / chemistry*
  • Humans
  • Image Processing, Computer-Assisted
  • Mass Screening / instrumentation
  • Mass Screening / methods*
  • Molecular Sequence Data
  • Peptides / chemistry
  • Photons
  • Spectroscopy, Near-Infrared / instrumentation
  • Spectroscopy, Near-Infrared / methods*
  • Tomography / instrumentation
  • Tomography / methods

Substances

  • Contrast Media
  • Fluorescent Dyes
  • Peptides