Abstract
Ankylosing spondylitis is a common inflammatory rheumatic disease. Both susceptibility to and clinical manifestations of the disease are highly heritable. Although some genes, notably HLA-B27, have been implicated in susceptibility to the disease, the genetics of the condition are complex and many more genes involved in the condition await discovery.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Chromosome Mapping
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HLA-B27 Antigen / genetics
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HLA-DR Antigens / genetics
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HLA-DRB1 Chains
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Humans
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Major Histocompatibility Complex / genetics
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Severity of Illness Index
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Spondylitis, Ankylosing / genetics*
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Spondylitis, Ankylosing / physiopathology
Substances
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HLA-B27 Antigen
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HLA-DR Antigens
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HLA-DRB1 Chains