Genetics of ankylosing spondylitis

Clin Exp Rheumatol. 2002 Nov-Dec;20(6 Suppl 28):S43-9.

Abstract

Ankylosing spondylitis is a common inflammatory rheumatic disease. Both susceptibility to and clinical manifestations of the disease are highly heritable. Although some genes, notably HLA-B27, have been implicated in susceptibility to the disease, the genetics of the condition are complex and many more genes involved in the condition await discovery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chromosome Mapping
  • HLA-B27 Antigen / genetics
  • HLA-DR Antigens / genetics
  • HLA-DRB1 Chains
  • Humans
  • Major Histocompatibility Complex / genetics
  • Severity of Illness Index
  • Spondylitis, Ankylosing / genetics*
  • Spondylitis, Ankylosing / physiopathology

Substances

  • HLA-B27 Antigen
  • HLA-DR Antigens
  • HLA-DRB1 Chains