HLA-DQ8 as an Ir gene in coeliac disease

K E A Lundin

doi:10.1136/gut.52.1.7

HLA-DQ8 as an Ir gene in coeliac disease

Gut. 2003 Jan;52(1):7-8. doi: 10.1136/gut.52.1.7.

Author

K E A Lundin¹

Affiliation

¹ Department of Medicine and Institute of Immunology, Rikshospitalet, N-0027 Oslo, Norway. knut.lundin@rikshospitalet.no

Abstract

DQ8 restricted gliadin peptide is immunogenic in the intestinal mucosa of HLA-DQ8 positive patients, representing the first demonstration that a given peptide may be of pathogenic significance only for a subset of coeliacs, and strongly suggests that DQ2 and DQ8 act as immune response (Ir) genes in this disease

Publication types

Comment

MeSH terms

Celiac Disease / genetics
Celiac Disease / immunology*
Genes, MHC Class II*
Gliadin / immunology
HLA-DQ Antigens / genetics*
Humans
Intestinal Mucosa / immunology*
Intestine, Small*

Substances

HLA-DQ Antigens
HLA-DQ2 antigen
HLA-DQ8 antigen
Gliadin