Abstract
A Palauan collection of the marine cyanobacterium Lyngbya sp., which had already afforded diverse peptide-based cytotoxins, also yielded a new glycoside macrolide exhibiting slight cytotoxicity. The compound was termed lyngbyaloside B (1) due to its structural analogy to the previously isolated lyngbyaloside (2). Lyngbyaloside B (1) appears to be only the third glycoside macrolide and second brominated compound of its kind from a marine cyanobacterium. Its gross structure was determined by a combination of NMR spectroscopy and mass spectrometric techniques. The relative stereochemistry for the 12 stereocenters is proposed on the basis of proton-proton spin-coupling constants and ROESY data.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cyanobacteria / chemistry*
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Drug Screening Assays, Antitumor
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Humans
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Inhibitory Concentration 50
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KB Cells / drug effects
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Lyngbya Toxins / chemistry
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Lyngbya Toxins / isolation & purification*
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Lyngbya Toxins / pharmacology
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Macrolides / chemistry
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Macrolides / isolation & purification*
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Macrolides / pharmacology
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Palau
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Stereoisomerism
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Tumor Cells, Cultured / drug effects
Substances
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Glycosides
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Lyngbya Toxins
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Macrolides
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lyngbyaloside B