Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species

Chem Commun (Camb). 2002 Nov 21:(22):2730-1. doi: 10.1039/b208760j.

Abstract

Motexafin gadolinium (MGd) oxidizes ascorbate, in neutral buffer and in cell culture, forming reactive oxygen species and a coordination polymer with oxalate.

MeSH terms

  • Ascorbic Acid / chemistry
  • Ascorbic Acid / metabolism*
  • Metalloporphyrins / chemistry
  • Metalloporphyrins / metabolism*
  • Metalloporphyrins / pharmacology
  • Molecular Structure
  • Oxalic Acid / chemistry
  • Oxalic Acid / metabolism
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / metabolism*
  • Photosensitizing Agents / pharmacology
  • Polymers / chemistry
  • Polymers / metabolism
  • Reactive Oxygen Species / chemistry
  • Reactive Oxygen Species / metabolism*
  • Tumor Cells, Cultured

Substances

  • Metalloporphyrins
  • Photosensitizing Agents
  • Polymers
  • Reactive Oxygen Species
  • motexafin gadolinium
  • Oxalic Acid
  • Ascorbic Acid