Objective: To investigate actions of Total Paeony Glycoside (TPG) on cerebral ischemia-reperfusion model in mice.
Methods: The cerebral ischemia-reperfusion models induced by lagation of bilateral common carotid arteries incompletely were used.
Results: It was found that TPG could improve the learning and memory capacity of model mice in step down test. TPG significantly reduced the decrease of superoxide dismutase(SOD), inhibited the increase of nitric oxide(NO) and lessened the level of malondialdehyde(MDA) in model mice. 75 mg.kg-1 TPG also reduced the decrease of lactate dehydrogenase (LDH) in cerebrum remarkedly.
Conclusion: It is suggested that TPG possess obvious protective effects against cerebral ischemia-reperfusion mice.