Objective: To explore the therapeutic effect and mechanism of Bushen Huoxue Xiezhuo Decoction (BHXD) in treating minimal change nephropathy (MCN) in rats.
Methods: The MCN model rats established by a single intravenous injection of Adriamycin were divided into the model, BHXD group, and a normal group was set up for control. The effect of treatment on renal function, hemorrheologic parameters, renal tissue TGF-beta 1 expression and polyanion sites on glomerular basement membrane were observed dynamically.
Results: After treatment, all the parameters between the BHXD group and the model group were significantly different respectively, morphological observation also showed the pathological changes in the BHXD group were milder than those in the model group.
Conclusion: BHXD treatment could markedly improve the renal function, alleviate blood hypercoagulability and hyperviscosity, protect the anion barrier and delay the progression of glomerular fibrosis and sclerosis.