Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women

K-M Lee; J Abel; Y Ko; V Harth; W-Y Park; J-S Seo; K-Y Yoo; J-Y Choi; A Shin; S-H Ahn; D-Y Noh; A Hirvonen; D Kang

doi:10.1038/sj.bjc.6600761

Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women

Br J Cancer. 2003 Mar 10;88(5):675-8. doi: 10.1038/sj.bjc.6600761.

Authors

K-M Lee¹, J Abel, Y Ko, V Harth, W-Y Park, J-S Seo, K-Y Yoo, J-Y Choi, A Shin, S-H Ahn, D-Y Noh, A Hirvonen, D Kang

Affiliation

¹ Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, Chongno-Gu, Seoul, Korea.

Abstract

A case-control study was performed to assess the potential influence of CYP19 Arg(264)Cys and CYP1B1 Leu(432)Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg(264)Cys polymorphism modifies breast cancer risk (OR=1.5, 95% CI=1.1-2.2), especially in association with alcohol consumption (P for interaction=0.04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Alcohol Drinking / adverse effects*
Aromatase / genetics*
Aryl Hydrocarbon Hydroxylases / genetics*
Base Sequence
Breast Neoplasms / epidemiology*
Breast Neoplasms / genetics
Case-Control Studies
Cytochrome P-450 CYP1B1
DNA Primers
Female
Humans
Middle Aged
Odds Ratio
Polymorphism, Genetic*
Risk Factors

Substances

DNA Primers
Aromatase
Aryl Hydrocarbon Hydroxylases
CYP1B1 protein, human
Cytochrome P-450 CYP1B1