Anti-inflammatory and antinociceptive activities of Loasa speciosa in rats and mice

Fitoterapia. 2003 Feb;74(1-2):45-51. doi: 10.1016/s0367-326x(02)00299-x.

Abstract

In the range of doses of 250-500 mg/kg (given i.p.) the aqueous extract of Loasa speciosa leaves showed an inhibitory effect on leukocyte migration, and a reduction on the pleural exudate, as well as dose-dependent anti-inflammatory and peripheral antinociceptive activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / administration & dosage
  • Analgesics / pharmacology*
  • Analgesics / therapeutic use
  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Inflammatory Agents / therapeutic use
  • Carrageenan
  • Cornaceae*
  • Dose-Response Relationship, Drug
  • Edema / chemically induced
  • Edema / prevention & control
  • Female
  • Formaldehyde
  • Injections, Intraperitoneal
  • Leukocytes / drug effects*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Pain / chemically induced
  • Pain / prevention & control
  • Pain Measurement / drug effects
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Leaves
  • Pleurisy / chemically induced
  • Pleurisy / prevention & control
  • Rats
  • Rats, Wistar

Substances

  • Analgesics
  • Anti-Inflammatory Agents
  • Plant Extracts
  • Formaldehyde
  • Carrageenan