Corneal flap complications in refractive surgery: Part 1: development of an experimental animal model

J Cataract Refract Surg. 2003 Apr;29(4):795-802. doi: 10.1016/s0886-3350(03)00096-8.

Abstract

Purpose: To report the outcome, learning curve, and complication rates of an experimental animal model for corneal flaps in refractive surgery.

Setting: Magill Research Center for Vision Correction, Storm Eye Institute, Charleston, South Carolina, USA.

Methods: Corneal flaps with a nasal or a temporal hinge were created in 190 eyes of 95 Dutch Belted rabbits using the Automated Corneal Shaper microkeratome (Bausch & Lomb Surgical). Diffuse lamellar keratitis (DLK) was induced by inoculating the corneal interfaces with 1 of 7 substances. Postoperatively, the eyes were examined with a slitlamp. Special emphasis was placed on corneal flap complications and the relationship between slipped flaps and hinge position and/or inoculation agent.

Results: A good corneal flap was achieved in 174 eyes (92%). The eyes with a nasal hinge had a lower incidence of slipped flaps (14%) than eyes with a temporal hinge (37%) (P =.02).

Conclusion: With the animal model described, corneal flaps were created in a precise and reproducible way in more than 90% of eyes. Nasal hinged flaps showed less postoperative displacements than temporal hinged flaps and are adequate for further study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Corneal Stroma / surgery*
  • Disease Models, Animal*
  • Intraoperative Complications*
  • Keratitis / etiology
  • Postoperative Complications*
  • Rabbits
  • Refractive Surgical Procedures*
  • Surgical Flaps / adverse effects*