Abstract
The biosynthetic origin of the C(3) unit, C-6,5,5', of pyridoxamine was investigated in two yeasts, Candida utilis ATCC 9256 and Saccharomyces cerevisiae ATCC 7752. The incorporation patterns within pyridoxamine bishydrochloride derived from variously multiply (13)C- and (2)H-labeled samples of glycerol and glyceraldehyde, established by NMR spectroscopy, indicate that the three-carbon unit C-6,5,5' of pyridoxamine is derived intact from a triose.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Candida / metabolism*
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Carbon Isotopes
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Deuterium
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Escherichia coli / metabolism
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Glyceraldehyde
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Glycerol
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pyridoxamine / biosynthesis*
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Saccharomyces cerevisiae / metabolism*
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Trioses / metabolism
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Vitamin B 6 / biosynthesis*
Substances
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Carbon Isotopes
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Trioses
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Glyceraldehyde
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Pyridoxamine
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Vitamin B 6
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Deuterium
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Glycerol