Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients

Ann Neurol. 2003 Jul;54(1):119-22. doi: 10.1002/ana.10617.

Abstract

Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios. Ann Neurol 2003;54:119-122

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Abatacept
  • Antigens, CD
  • Antigens, Differentiation / genetics*
  • CTLA-4 Antigen
  • Cohort Studies
  • DNA Primers / genetics
  • Genetic Predisposition to Disease
  • HLA-DR Antigens / genetics*
  • HLA-DR Serological Subtypes
  • Humans
  • Immunoblotting
  • Immunoconjugates*
  • Multiple Sclerosis / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / genetics
  • Promoter Regions, Genetic / genetics

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • DNA Primers
  • HLA-DR Antigens
  • HLA-DR Serological Subtypes
  • HLA-DR15 antigen
  • Immunoconjugates
  • Abatacept