Abstract
The apterous56f (ap56f) mutation leads to increases in juvenile hormone (JH) degradation levels and JH-esterase makes a greater contribution to the increase than JH-epoxide hydrolase. Dopamine levels in ap56f females, but not males, are higher than in wild-type. JH treatment of ap56f and wild-type females decreases their dopamine levels. ap56f females, but not males, produce less progeny. Survival under heat stress is dramatically decreased in ap56f females, but not males. ap56f flies show a stress reaction, as judged by changes in tyrosine decarboxylase and JH-hydrolysing activities, dopamine levels and fertility, but its intensity in the mutant females, but not males, differs significantly from wild-type. Thus, the ap56f mutation causes dramatic changes in female, but not male, metabolism and fitness.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Blotting, Northern
-
Carboxylic Ester Hydrolases / metabolism
-
Dopamine / metabolism
-
Drosophila Proteins / genetics*
-
Drosophila melanogaster / genetics
-
Drosophila melanogaster / metabolism*
-
Epoxide Hydrolases
-
Female
-
Fertility / physiology
-
Gene Expression
-
HSP70 Heat-Shock Proteins / biosynthesis
-
HSP70 Heat-Shock Proteins / genetics
-
HSP70 Heat-Shock Proteins / metabolism
-
Heat Stress Disorders / enzymology
-
Heat Stress Disorders / metabolism*
-
Homeodomain Proteins / genetics*
-
Juvenile Hormones / deficiency*
-
Juvenile Hormones / metabolism
-
LIM-Homeodomain Proteins
-
Male
-
Mutation
-
Transcription Factors / genetics*
-
Tyrosine Decarboxylase / metabolism
Substances
-
Drosophila Proteins
-
HSP70 Heat-Shock Proteins
-
Homeodomain Proteins
-
Juvenile Hormones
-
LIM-Homeodomain Proteins
-
Transcription Factors
-
ap protein, Drosophila
-
Carboxylic Ester Hydrolases
-
juvenile hormone esterase
-
Epoxide Hydrolases
-
juvenile hormone epoxide hydrolase
-
Tyrosine Decarboxylase
-
Dopamine