Abstract
Resistance to quinupristin-dalfopristin (Q/D) among gram-positive cocci has been very uncommon. Two clinical isolates among 8,837 (0.02%) Streptococcus pneumoniae isolates were discovered in 2001 to 2002 with Q/D MICs of 4 micro g/ml. Each had a 5-amino-acid tandem duplication (RTAHI) in the L22 ribosomal protein gene (rplV) preventing synergistic ribosomal binding of the streptogramin combination. Similar gene duplication has been reported in Q/D-resistant Staphylococcus aureus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Base Sequence
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Community-Acquired Infections / drug therapy
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Community-Acquired Infections / microbiology
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Drug Resistance, Bacterial
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Humans
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Molecular Sequence Data
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Mutation / genetics*
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Pneumonia, Pneumococcal / microbiology*
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Population Surveillance
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RNA-Binding Proteins / genetics*
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Reverse Transcriptase Polymerase Chain Reaction
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Ribosomal Proteins*
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / genetics*
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United Kingdom
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Virginiamycin / analogs & derivatives*
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Virginiamycin / pharmacology*
Substances
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Anti-Bacterial Agents
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RNA-Binding Proteins
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Ribosomal Proteins
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Virginiamycin
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RPL22 protein, human
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quinupristin