Genetics of autoimmune myasthenia gravis, a model for antibody-mediated autoimmunity in man

J Autoimmun. 2003 Sep;21(2):105-10. doi: 10.1016/s0896-8411(03)00095-7.

Abstract

Autoimmune myasthenia gravis is an antibody-mediated autoimmune disease of the neuromuscular junction aimed at the muscle acetylcholine receptor. Recent genetic analyses focusing on a nonclass II HLA-linked locus, MYAS1, and on one of the genes encoding the AChR self-antigen, CHRNA1, are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoantibodies / immunology*
  • Autoantigens / metabolism
  • Autoimmunity
  • Female
  • Humans
  • Major Histocompatibility Complex / genetics
  • Male
  • Myasthenia Gravis / genetics*
  • Myasthenia Gravis / immunology
  • Phenotype
  • Receptors, Cholinergic / genetics
  • Receptors, Cholinergic / metabolism
  • Twins, Dizygotic / genetics
  • Twins, Monozygotic / genetics

Substances

  • Autoantibodies
  • Autoantigens
  • Receptors, Cholinergic