T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura

Nat Med. 2003 Sep;9(9):1123-4. doi: 10.1038/nm921. Epub 2003 Aug 24.

Abstract

Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Platelets / immunology*
  • Blood Platelets / physiology
  • Case-Control Studies
  • Cytotoxicity, Immunologic / genetics*
  • Granzymes
  • Humans
  • Interferon-gamma / genetics
  • Membrane Glycoproteins / genetics
  • Oligonucleotide Array Sequence Analysis
  • Perforin
  • Pore Forming Cytotoxic Proteins
  • Purpura, Thrombocytopenic, Idiopathic / blood
  • Purpura, Thrombocytopenic, Idiopathic / genetics*
  • Purpura, Thrombocytopenic, Idiopathic / immunology*
  • Receptors, Immunologic / genetics
  • Receptors, Interleukin-2 / genetics
  • Receptors, KIR
  • Serine Endopeptidases / genetics
  • T-Lymphocytes, Cytotoxic / immunology*
  • T-Lymphocytes, Cytotoxic / physiology

Substances

  • Membrane Glycoproteins
  • Pore Forming Cytotoxic Proteins
  • Receptors, Immunologic
  • Receptors, Interleukin-2
  • Receptors, KIR
  • Perforin
  • Interferon-gamma
  • GZMB protein, human
  • Granzymes
  • Serine Endopeptidases