Application of a synthetic analogue of leu-enkephalin (Dalargin) in alcohol withdrawal

Drug Alcohol Depend. 1992 Aug;30(3):209-13. doi: 10.1016/0376-8716(92)90054-g.

Abstract

The effects of 1 mg of a synthetic analogue of leu-enkephalin (Dalargin) injected intramuscular twice daily for 3 consecutive days were studied in 20 patients with alcohol withdrawal syndrome. The results suggest that the therapeutic effects of Dalargin in alcohol withdrawal syndrome are mainly connected with the changes in the dopamine-, serotonin-, GABA- and opioid-ergic neurotransmitters systems.

MeSH terms

  • Adrenocorticotropic Hormone / blood
  • Adult
  • Dopamine / blood
  • Enkephalin, Leucine-2-Alanine / administration & dosage
  • Enkephalin, Leucine-2-Alanine / analogs & derivatives*
  • Ethanol / adverse effects*
  • Humans
  • Male
  • Serotonin / blood
  • Substance Withdrawal Syndrome / blood
  • Substance Withdrawal Syndrome / drug therapy*
  • Sympatholytics / administration & dosage*
  • gamma-Aminobutyric Acid / blood

Substances

  • Sympatholytics
  • Serotonin
  • Ethanol
  • gamma-Aminobutyric Acid
  • Enkephalin, Leucine-2-Alanine
  • Adrenocorticotropic Hormone
  • enkephalin-Leu, Ala(2)-Arg(6)-
  • Dopamine