Three cases of odontogenic myxoma are presented, two of which were located in the mandible and one in the maxilla. All cases demonstrated similar morphology by light microscopy. Immunohistochemical studies demonstrated positive reaction with antibodies to vimentin and actin, and negative reaction to antibody to S-100 protein. A 127-day-old human tooth bud was used as a control. The ultrastructural features performed on Case 3, when combined with the immunohistochemical findings suggest that the cells comprising odontogenic myxoma are of myofibroblastic origin.