Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels

Twin Res. 2003 Aug;6(4):322-4. doi: 10.1375/136905203322296692.

Abstract

Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Twin Study

MeSH terms

  • Adolescent
  • Chromosomes, Human, Pair 1
  • Chromosomes, Human, Pair 6
  • Genetic Linkage*
  • Humans
  • Lipoproteins / genetics*
  • Quantitative Trait Loci*
  • Twins / genetics*
  • Twins, Dizygotic
  • Twins, Monozygotic

Substances

  • Lipoproteins