Stereocontrolled synthesis of diene and enyne sugar-modified nucleosides and their interaction with S-adenosyl-L-homocysteine hydrolase

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):783-5. doi: 10.1081/NCN-120022634.

Abstract

Conjugated diene 5-7 and enyne 8 analogs derived from adenosine and uridine were synthesized employing Pd-catalyzed cross-coupling reactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosylhomocysteinase / metabolism*
  • Indicators and Reagents
  • Kinetics
  • NAD / metabolism
  • Nucleosides / chemical synthesis*
  • Nucleosides / metabolism*
  • Substrate Specificity

Substances

  • Indicators and Reagents
  • Nucleosides
  • NAD
  • Adenosylhomocysteinase