In Germany, four different drug eluting stents (DES) systems are currently commercially available. Whereas sirolimus has been clinically tested in only a single type of stent with a single type of coating in only a single dose, paclitaxel has been tested on various stent designs, in various dose densities, and in various release formulations with or without a polymer carrier. Therefore, the question arises: are all paclitaxel stents equally safe and effective? Six clinical randomized trials investigated the safety and efficacy of paclitaxel-eluting stents in patients with de-novo lesions: TAXUS-I (61 pats), TAXUS-II (536 pats), ASPECT (177 pats), ELUTES (190 pats), DELIVER-I (1041 pats) and TAXUS-IV (1314 pats). In the TAXUS-series, paclitaxel released from the stent was controlled by the Translute polymer. In the other studies, however, no polymer carrier was used. In TAXUS-I, II & IV, the dose density of 1 microg/mm2 significantly reduced angiographic parameters of restenosis and improved clinical outcomes. In ASPECT and ELUTES there was a dose-dependent effect on angiographic parameters of restenosis with the best results for a paclitaxel dose density of approximately 3.0 microg/mm2. Clinical outcomes at 6 and 12 months, however, were not improved in these studies without coating. The studies unanimously show that the paclitaxel-eluting stents are safe, if clopidogrel is added to ASA for 3 to 6 months. The safety of paclitaxel-eluting stents is independent of the stent design, the dose density and the presence or absence of a polymer carrier system. For paclitaxel-eluting stents using a polymer carrier, the dose density of 1 microg/mm2 is highly effective, whereas for paclitaxel-eluting stents without a polymer carrier, the minimal effective dose density is much higher (3 microg/mm2). Despite their improvement of angiographic parameters, paclitaxel-eluting stents without a polymer carrier did not demonstrate a positive effect on clinical outcome. In contrast, polymer-based paclitaxel elution produced significant clinical benefit.