Comparative in vitro susceptibilities and bactericidal activities of investigational fluoroquinolone ABT-492 and other antimicrobial agents against human mycoplasmas and ureaplasmas

Ken B Waites; Donna M Crabb; Lynn B Duffy

doi:10.1128/AAC.47.12.3973-3975.2003

Comparative in vitro susceptibilities and bactericidal activities of investigational fluoroquinolone ABT-492 and other antimicrobial agents against human mycoplasmas and ureaplasmas

Antimicrob Agents Chemother. 2003 Dec;47(12):3973-5. doi: 10.1128/AAC.47.12.3973-3975.2003.

Authors

Ken B Waites¹, Donna M Crabb, Lynn B Duffy

Affiliation

¹ Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA. waites@path.uab.edu

Abstract

We determined in vitro susceptibilities for ABT-492 and other antimicrobials against Mycoplasma pneumoniae, Mycoplasma fermentans, Mycoplasma hominis, and Ureaplasma species. ABT-492 MICs were < or =1 microg/ml, and the agent was bactericidal against selected isolates of M. pneumoniae and M. hominis. ABT-492 has potential for treatment of infections due to these microorganisms.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / pharmacology*
Fluoroquinolones
Humans
Microbial Sensitivity Tests
Mycoplasma / drug effects*
Mycoplasma fermentans / drug effects
Mycoplasma hominis / drug effects
Mycoplasma pneumoniae / drug effects
Quinolones / pharmacology*
Ureaplasma / drug effects*

Substances

Anti-Infective Agents
Fluoroquinolones
Quinolones
delafloxacin