Design and syntheses of melanocortin subtype-4 receptor agonists: evolution of the pyridazinone archetype

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4431-5. doi: 10.1016/j.bmcl.2003.09.026.

Abstract

The discovery and optimization of a new class of non-peptidyl, pyridazinone derived melanocortin subtype-4 receptor agonists is disclosed.

MeSH terms

  • Animals
  • Binding Sites
  • Humans
  • Indicators and Reagents
  • Kinetics
  • Mice
  • Molecular Conformation
  • Pyridazines / chemical synthesis*
  • Pyridazines / chemistry
  • Pyridazines / pharmacology*
  • Receptor, Melanocortin, Type 4 / agonists*
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Indicators and Reagents
  • Pyridazines
  • Receptor, Melanocortin, Type 4