Abstract
In this article, Courtney Smith and Eric Davidson reinterpret the published data on immune function in lower deuterostomes and primitive chordates. It leads them to a new model of immune system phylogeny in which MHC-directed T-cell responses are the last to evolve and are not derived from subchordate self-nonself recognition systems.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibody Formation
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Chordata, Nonvertebrate / immunology*
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Echinodermata / immunology*
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Fishes / immunology
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Immunity, Cellular
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Models, Biological
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Phylogeny*
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Reproduction / immunology
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Sea Urchins / immunology
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Species Specificity
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Transplantation, Homologous / immunology
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Urochordata / immunology*