Disease screening is one of important activities in the domain of public health. However, traditional disease screening is based on solitary disease rather than multiple diseases. Although information accrued from multiple screening make contribution to health risk assessment as well as efficient management, data sources underpinning multiple screening are diversified and complicated including registration, primary data from questionnaire or biological measurement, referral system, confirmatory diagnosis, and case management. As our multiple screening integrates five types of cancers and four types of chronic disease at each out-reach and ambulatory setting, packages for attendants vary according to age, gender and risk factor (such as betel chewing, alcohol drink, smoking, family history, self-disease history, etc.). We took the initiative in design of health information system to support the complex processes of multiple screening. To enhance the efficiency of multiple screening and efficient disease management, health information system was therefore designed to support such a complicated infrastructure.