Abstract
We used Na(+)-Ca(2+) exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mice hearts after ischemia/reperfusion and the infarct size was significantly small in NCX KO mice hearts compared with that in WT mice hearts. NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcium / chemistry
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Calcium / metabolism
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Disease Models, Animal
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Heart / physiopathology
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Hemodynamics / physiology
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Heterozygote
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Male
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Mice
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Mice, Knockout
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Myocardial Infarction / metabolism
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Myocardial Ischemia / metabolism*
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Myocardial Reperfusion Injury / metabolism*
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Myocardial Reperfusion Injury / physiopathology
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Myocardium / metabolism
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Myocardium / pathology
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Myocytes, Cardiac / physiology
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Sodium-Calcium Exchanger / genetics
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Sodium-Calcium Exchanger / metabolism
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Sodium-Calcium Exchanger / physiology*
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Staining and Labeling / methods
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Tetrazolium Salts / chemistry
Substances
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Sodium-Calcium Exchanger
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Tetrazolium Salts
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Calcium