Role of Na+-Ca2+ exchanger in myocardial ischemia/reperfusion injury: evaluation using a heterozygous Na+-Ca2+ exchanger knockout mouse model

Biochem Biophys Res Commun. 2004 Feb 13;314(3):849-53. doi: 10.1016/j.bbrc.2003.12.165.

Abstract

We used Na(+)-Ca(2+) exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mice hearts after ischemia/reperfusion and the infarct size was significantly small in NCX KO mice hearts compared with that in WT mice hearts. NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / chemistry
  • Calcium / metabolism
  • Disease Models, Animal
  • Heart / physiopathology
  • Hemodynamics / physiology
  • Heterozygote
  • Male
  • Mice
  • Mice, Knockout
  • Myocardial Infarction / metabolism
  • Myocardial Ischemia / metabolism*
  • Myocardial Reperfusion Injury / metabolism*
  • Myocardial Reperfusion Injury / physiopathology
  • Myocardium / metabolism
  • Myocardium / pathology
  • Myocytes, Cardiac / physiology
  • Sodium-Calcium Exchanger / genetics
  • Sodium-Calcium Exchanger / metabolism
  • Sodium-Calcium Exchanger / physiology*
  • Staining and Labeling / methods
  • Tetrazolium Salts / chemistry

Substances

  • Sodium-Calcium Exchanger
  • Tetrazolium Salts
  • Calcium