Small open reading frames in 5' untranslated regions of mRnas

Riu Yamashita; Yutaka Suzuki; Kenta Nakai; Sumio Sugano

doi:10.1016/j.crvi.2003.09.028

Small open reading frames in 5' untranslated regions of mRnas

C R Biol. 2003 Oct-Nov;326(10-11):987-91. doi: 10.1016/j.crvi.2003.09.028.

Authors

Riu Yamashita¹, Yutaka Suzuki, Kenta Nakai, Sumio Sugano

Affiliation

¹ Laboratory of Genome Database, Human Genome Center, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan.

PMID: 14744105
DOI: 10.1016/j.crvi.2003.09.028

Abstract

Using the 5'-end sequence data from 'oligo-capped' cDNAs, we generated a representative full-length cDNA dataset for 4870 RefSeq entries, and analyzed the 5' untranslated region (UTR) of these genes. To our surprise, about half of the 4870 genes had an upstream ATG before the ATG that starts the longest open reading frame (ORF), suggesting that about half of them have small ORFs in their 5' UTR of average length of 31 amino acids. They require attention for further analysis to identify their biological role.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

5' Untranslated Regions / genetics*
DNA, Complementary
Humans
Open Reading Frames / genetics*

Substances

5' Untranslated Regions
DNA, Complementary