Abstract
The dopamine D2 receptor gene is a candidate gene for schizophrenia. We screened three exons of this gene for mutations in a large sample of schizophrenics, delusional patients and healthy controls. No structural changes were found, thus suggesting that psychopathology is not related to DNA alterations in the DRD2 gene.
MeSH terms
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Adult
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Alleles
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Delusions / genetics*
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Delusions / psychology
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Electrophoresis*
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Exons / genetics*
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Female
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Gene Frequency / genetics
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Humans
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Male
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Middle Aged
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Mutation / genetics
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Polymerase Chain Reaction*
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Polymorphism, Genetic / genetics*
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Receptors, Dopamine D2 / genetics*
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Schizophrenia / genetics*
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Schizophrenic Psychology*
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Signal Transduction / genetics