Use of polymerase chain reaction nad denaturing gradient gel electrophoresis to identify polymorphisms in three exons of dopamine D2 receptor gene in schizophrenic and delusional patients

Neuropsychobiology. 1992;26(1-2):1-3. doi: 10.1159/000118888.

Abstract

The dopamine D2 receptor gene is a candidate gene for schizophrenia. We screened three exons of this gene for mutations in a large sample of schizophrenics, delusional patients and healthy controls. No structural changes were found, thus suggesting that psychopathology is not related to DNA alterations in the DRD2 gene.

MeSH terms

  • Adult
  • Alleles
  • Delusions / genetics*
  • Delusions / psychology
  • Electrophoresis*
  • Exons / genetics*
  • Female
  • Gene Frequency / genetics
  • Humans
  • Male
  • Middle Aged
  • Mutation / genetics
  • Polymerase Chain Reaction*
  • Polymorphism, Genetic / genetics*
  • Receptors, Dopamine D2 / genetics*
  • Schizophrenia / genetics*
  • Schizophrenic Psychology*
  • Signal Transduction / genetics

Substances

  • Receptors, Dopamine D2