Confirmation of the protective effect of iNOS in an independent cohort of Parkinson disease

Neurology. 2004 Feb 24;62(4):635-6. doi: 10.1212/01.wnl.0000110191.38152.29.

Abstract

Nitric oxide is a biologic messenger molecule involved in a diverse range of physiologic processes. An exon 22 inducible nitric oxide synthase genotype has recently been reported to be protective against Parkinson disease in a European cohort. The authors confirm the protective effect of this genotype (OR = 0.5, 95% CI 0.27 to 0.93) in an independent Finnish case-control series.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Case-Control Studies
  • Exons / genetics
  • Female
  • Finland / epidemiology
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Humans
  • Linkage Disequilibrium
  • Male
  • Middle Aged
  • Nitric Oxide / physiology*
  • Nitric Oxide Synthase / physiology*
  • Nitric Oxide Synthase Type II
  • Parkinson Disease / enzymology*
  • Parkinson Disease / epidemiology

Substances

  • Nitric Oxide
  • NOS2 protein, human
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type II