Abstract
We studied CD4 T cell activation in patients with clinically isolated syndromes (CIS) suggesting an initial attack of multiple sclerosis. The percentage of blood CD26+ CD4 T cells was increased in these patients, and correlated with magnetic resonance imaging disease activity and clinical disease severity. In contrast, the percentage of CD25+ CD4 T cells in cerebrospinal fluid correlated negatively with the cerebrospinal fluid concentration of myelin basic protein and the presence of IgG oligoclonal bands. These results suggest that distinct systemic and intrathecal T cell activation states correlate with disease activity and risk of subsequently developing MS in CIS patients.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antigens, Differentiation / blood
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Antigens, Differentiation / cerebrospinal fluid
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CD4-Positive T-Lymphocytes / immunology*
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Dipeptidyl Peptidase 4 / blood
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Dipeptidyl Peptidase 4 / cerebrospinal fluid
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Disability Evaluation
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Female
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Flow Cytometry / methods
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Humans
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Immunoglobulin G / blood
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Immunoglobulin G / cerebrospinal fluid
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Lymphocyte Activation / immunology*
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Magnetic Resonance Imaging / methods
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Male
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Middle Aged
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Multiple Sclerosis / blood
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Multiple Sclerosis / cerebrospinal fluid
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Multiple Sclerosis / immunology*
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Myelin Basic Protein / blood
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Myelin Basic Protein / cerebrospinal fluid
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Nervous System Diseases / blood
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Nervous System Diseases / immunology
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Nervous System Diseases / physiopathology
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Receptors, Interleukin-2 / metabolism
Substances
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Antigens, Differentiation
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Immunoglobulin G
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Myelin Basic Protein
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Receptors, Interleukin-2
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Dipeptidyl Peptidase 4