CD4 T cell activation and disease activity at onset of multiple sclerosis

J Neuroimmunol. 2004 Apr;149(1-2):202-9. doi: 10.1016/j.jneuroim.2003.12.019.

Abstract

We studied CD4 T cell activation in patients with clinically isolated syndromes (CIS) suggesting an initial attack of multiple sclerosis. The percentage of blood CD26+ CD4 T cells was increased in these patients, and correlated with magnetic resonance imaging disease activity and clinical disease severity. In contrast, the percentage of CD25+ CD4 T cells in cerebrospinal fluid correlated negatively with the cerebrospinal fluid concentration of myelin basic protein and the presence of IgG oligoclonal bands. These results suggest that distinct systemic and intrathecal T cell activation states correlate with disease activity and risk of subsequently developing MS in CIS patients.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antigens, Differentiation / blood
  • Antigens, Differentiation / cerebrospinal fluid
  • CD4-Positive T-Lymphocytes / immunology*
  • Dipeptidyl Peptidase 4 / blood
  • Dipeptidyl Peptidase 4 / cerebrospinal fluid
  • Disability Evaluation
  • Female
  • Flow Cytometry / methods
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin G / cerebrospinal fluid
  • Lymphocyte Activation / immunology*
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / cerebrospinal fluid
  • Multiple Sclerosis / immunology*
  • Myelin Basic Protein / blood
  • Myelin Basic Protein / cerebrospinal fluid
  • Nervous System Diseases / blood
  • Nervous System Diseases / immunology
  • Nervous System Diseases / physiopathology
  • Receptors, Interleukin-2 / metabolism

Substances

  • Antigens, Differentiation
  • Immunoglobulin G
  • Myelin Basic Protein
  • Receptors, Interleukin-2
  • Dipeptidyl Peptidase 4