A genome scan in 260 inflammatory bowel disease-affected relative pairs

M Michael Barmada; Steven R Brant; Dan L Nicolae; Jean-Paul Achkar; Carolien I Panhuysen; Theodore M Bayless; Judy H Cho; Richard H Duerr

doi:10.1097/00054725-200401000-00002

A genome scan in 260 inflammatory bowel disease-affected relative pairs

Inflamm Bowel Dis. 2004 Jan;10(1):15-22. doi: 10.1097/00054725-200401000-00002.

Authors

M Michael Barmada¹, Steven R Brant, Dan L Nicolae, Jean-Paul Achkar, Carolien I Panhuysen, Theodore M Bayless, Judy H Cho, Richard H Duerr

Affiliation

¹ Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

PMID: 15058521
DOI: 10.1097/00054725-200401000-00002

Abstract

We report the results of a new genome scan in 260 IBD-affected relative pairs from 139 families that we have recruited since our previous IBD genome scans were performed. The goal of our study was to determine whether we could extend the linkage evidence in any of the more than 20 regions with nominal evidence for linkage to IBD in previous individual genome scans in order to prioritize regions for further study.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Colitis, Ulcerative / genetics*
Crohn Disease / genetics*
Genetic Linkage
Genetic Predisposition to Disease*
Genotype
Humans
Pedigree

Abstract

Publication types

MeSH terms

Grants and funding