Catheter-based treatment for patients with acute ischemic stroke ineligible for intravenous thrombolysis

Stroke. 2004 May;35(5):e109-11. doi: 10.1161/01.STR.0000125711.94465.78. Epub 2004 Apr 15.

Abstract

Background and purpose: We present our single-center experience using catheter-based therapy for acute ischemic stroke patients who were not candidates for intravenous thrombolytic therapy.

Methods: Neurologic outcomes were assessed in patients with acute ischemic stroke, ineligible for intravenous thrombolysis, treated with an emergent catheter-based therapy.

Results: Nonparametric analysis of neurological outcomes demonstrated a benefit in National Institutes of Health Stroke Scale (NIHSS) at long-term follow-up (P=0.036). Independence in daily activities and improvement in NIHSS of > or =4 points were achieved in 38% and 56% of patients, respectively. Four patients (25%) died, including 2 patients (12.5%) who died from intracranial hemorrhage.

Conclusions: Catheter-based treatment offers a promising treatment strategy in patients with acute ischemic stroke ineligible for intravenous thrombolysis.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Angioplasty, Balloon / methods*
  • Brain Ischemia / diagnosis
  • Brain Ischemia / drug therapy*
  • Brain Ischemia / therapy*
  • Female
  • Heparin / administration & dosage
  • Heparin / therapeutic use
  • Humans
  • Infarction, Middle Cerebral Artery / prevention & control
  • Infusions, Intra-Arterial
  • Intracranial Hemorrhages / prevention & control
  • Male
  • Severity of Illness Index
  • Statistics, Nonparametric
  • Stents
  • Stroke / diagnosis
  • Stroke / drug therapy*
  • Stroke / therapy*
  • Thrombolytic Therapy / methods*
  • Tissue Plasminogen Activator / therapeutic use
  • Treatment Outcome
  • Urokinase-Type Plasminogen Activator / therapeutic use

Substances

  • Heparin
  • Tissue Plasminogen Activator
  • Urokinase-Type Plasminogen Activator