Two multivariate methods, a logistic regression-derived algorithm and a Bayesian independence-assuming method (CADENZA), were compared concerning their abilities to estimate posttest probability of coronary disease in patients with suspected coronary disease. All patients underwent exercise testing within 3 months prior to coronary angiography. Coronary disease was defined as the presence of one or more vessels with greater than or equal to 50% luminal diameter narrowing. A group of 300 patients (disease prevalence = 37%) was used to derive the algorithm. Another group of 950 patients was used to validate the algorithm and compare it to CADENZA. Seven variables (age, sex, symptoms, diabetes, mm ST depression, ST slope, and peak heart rate) were used to generate posttest probabilities for each method. The receiver operating characteristic curve area for the logistic regression method (0.81 +/- 0.01) was significantly higher than CADENZA (0.75 +/- 0.01; p less than 0.05). There was, however, no difference in the calibration of the two methods. When given equivalent variable information, the logistic regression algorithm had better discrimination than CADENZA for estimating the probability of coronary disease following exercise electrocardiography.