Relation of an elevated white blood cell count after percutaneous coronary intervention to long-term mortality

Vivek Rajagopal; Hitinder S Gurm; Deepak L Bhatt; A Michael Lincoff; James E Tcheng; Dean J Kereiakes; Neal S Kleiman; Gang Jia; Eric J Topol

doi:10.1016/j.amjcard.2004.03.060

Relation of an elevated white blood cell count after percutaneous coronary intervention to long-term mortality

Am J Cardiol. 2004 Jul 15;94(2):190-2. doi: 10.1016/j.amjcard.2004.03.060.

Authors

Vivek Rajagopal¹, Hitinder S Gurm, Deepak L Bhatt, A Michael Lincoff, James E Tcheng, Dean J Kereiakes, Neal S Kleiman, Gang Jia, Eric J Topol

Affiliation

¹ The Cleveland Clinic Foundation, Cleveland, Ohio, USA.

PMID: 15246898
DOI: 10.1016/j.amjcard.2004.03.060

Abstract

Increased inflammatory markers are associated with a poor prognosis after percutaneous coronary intervention. Leukocytes play a key role in inflammation, and an increase in white blood cell (WBC) counts is a nonspecific marker of inflammation. In patients undergoing percutaneous coronary intervention, baseline WBC counts independently predict long-term mortality. In a pooled cohort of patients from the Evaluation of c7E3 for the Prevention of Ischemic Complications (EPIC), the Evaluation in PTCA to Improve Long-term Outcome with abciximab Glycoprotein IIb/IIIa blockade (EPILOG), and Evaluation of Platelet IIb/IIIa inhibitor for STENTing (EPISTENT) trials, postprocedural WBC counts were also found to be an independent predictor of long-term mortality.

MeSH terms

Aged
Angioplasty, Balloon, Coronary
Coronary Disease / mortality*
Coronary Disease / therapy*
Female
Humans
Leukocyte Count
Male
Middle Aged
Multicenter Studies as Topic
Multivariate Analysis
Prognosis
Randomized Controlled Trials as Topic
Retrospective Studies
Survival Analysis