Abstract
The introduction of copper chelates into peptide mimetics creates the Src SH2 binding ligands and paramagnetic complexes suitable for EPR studies of peptide protein interactions. The dipicolinic acid was attached to SH2 domain targeting fragments by two different linkers.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Copper / chemistry*
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Electron Spin Resonance Spectroscopy
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Ligands
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Magnetic Resonance Spectroscopy
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Molecular Mimicry
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Peptides / chemistry
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Peptides / metabolism*
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Picolinic Acids / chemistry
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Picolinic Acids / metabolism*
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src Homology Domains
Substances
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Ligands
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Peptides
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Picolinic Acids
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Copper
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dipicolinic acid