Insulin-like growth factor-I gene polymorphism and risk of heart failure (the Rotterdam Study)

Gysèle S Bleumink; Ingrid Rietveld; Joop A M J L Janssen; Elisabeth F C van Rossum; Jaap W Deckers; Albert Hofman; Jacqueline C M Witteman; Cornelia M van Duijn; Bruno H Ch Stricker

doi:10.1016/j.amjcard.2004.04.044

Insulin-like growth factor-I gene polymorphism and risk of heart failure (the Rotterdam Study)

Am J Cardiol. 2004 Aug 1;94(3):384-6. doi: 10.1016/j.amjcard.2004.04.044.

Authors

Gysèle S Bleumink¹, Ingrid Rietveld, Joop A M J L Janssen, Elisabeth F C van Rossum, Jaap W Deckers, Albert Hofman, Jacqueline C M Witteman, Cornelia M van Duijn, Bruno H Ch Stricker

Affiliation

¹ Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.

PMID: 15276114
DOI: 10.1016/j.amjcard.2004.04.044

Abstract

We studied 4,963 participants of the population-based Rotterdam Study and found that a genetically determined chronic exposure to low insulin-like growth factor-I (IGF-I) levels is associated with an increased risk for heart failure in elderly patients.

Publication types

Comparative Study

MeSH terms

Age Distribution
Alleles
Cohort Studies
Confidence Intervals
Female
Genetic Predisposition to Disease*
Heart Failure / epidemiology*
Heart Failure / genetics*
Humans
Incidence
Insulin-Like Growth Factor I / genetics*
Male
Polymorphism, Genetic*
Prognosis
Promoter Regions, Genetic
Proportional Hazards Models
Prospective Studies
Risk Assessment
Sex Distribution
Survival Analysis

Substances

Insulin-Like Growth Factor I