Abstract
Resveratrol inhibits PAH bioactivation through reduced expression of the CYP1A1 and CYP1B1 genes in human bronchial epithelial cells. Ad libitum access to a diet containing resveratrol showed no effect on benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Also, resveratrol did not change CYP1A1 and CYP1B1 gene expression or benzo[a]pyrene protein adduct levels in the lung tissue. The lack of chemopreventive activity may have been caused by insufficient concentrations or nonreactive forms of resveratrol in the lungs.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Angiogenesis Inhibitors / pharmacology*
-
Animals
-
Aryl Hydrocarbon Hydroxylases / biosynthesis*
-
Aryl Hydrocarbon Hydroxylases / genetics
-
Benzo(a)pyrene / administration & dosage
-
Benzo(a)pyrene / adverse effects
-
Chemoprevention
-
Cytochrome P-450 CYP1A1 / biosynthesis*
-
Cytochrome P-450 CYP1A1 / genetics
-
Cytochrome P-450 CYP1B1
-
Female
-
Gene Expression Regulation, Neoplastic / drug effects*
-
Lung Neoplasms / chemically induced
-
Lung Neoplasms / prevention & control*
-
Lung Neoplasms / veterinary
-
Mice
-
Phenols
-
Resveratrol
-
Reverse Transcriptase Polymerase Chain Reaction
-
Stilbenes / pharmacology*
Substances
-
Angiogenesis Inhibitors
-
Phenols
-
Stilbenes
-
Benzo(a)pyrene
-
Aryl Hydrocarbon Hydroxylases
-
CYP1B1 protein, human
-
Cyp1b1 protein, mouse
-
Cytochrome P-450 CYP1A1
-
Cytochrome P-450 CYP1B1
-
Resveratrol