Abstract
Fluoroquinolone-resistant isolates of Haemophilus influenzae, obtained from a long-term care facility, were examined for nucleotide sequence differences in the quinolone-resistance-determining regions of gyrA, gyrB, parC, and parE. Similarities among the resistant isolates, plus multiple differences with susceptible isolates, suggest clonal dissemination involving two resistant subclones.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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DNA Gyrase / biosynthesis
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DNA Gyrase / genetics*
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DNA Topoisomerase IV / biosynthesis
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DNA Topoisomerase IV / genetics*
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Drug Resistance, Bacterial
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Fluoroquinolones / pharmacology*
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Genes, Bacterial
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Haemophilus influenzae / drug effects*
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Humans
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Microbial Sensitivity Tests
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Skilled Nursing Facilities*
Substances
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Anti-Bacterial Agents
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Fluoroquinolones
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DNA Topoisomerase IV
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DNA Gyrase