Development of tyrosinase labile protecting groups for amines

Helen M I Osborn; Nana Aba O Williams

doi:10.1021/ol040042i

Development of tyrosinase labile protecting groups for amines

Org Lett. 2004 Sep 2;6(18):3111-3. doi: 10.1021/ol040042i.

Authors

Helen M I Osborn¹, Nana Aba O Williams

Affiliation

¹ School of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK. h.m.i.osborn@rdg.ac.uk

PMID: 15330600
DOI: 10.1021/ol040042i

Abstract

[reaction: see text] The development of two novel protecting groups for amines is described. Thus, a range of amines have been converted to ureas, and the deprotection of these upon exposure to mushroom tyrosinase (E.C. 1.14.18.1) has been demonstrated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Agaricales / enzymology*
Amines / chemistry*
Catalysis
Molecular Structure
Monophenol Monooxygenase / metabolism*
Urea / chemistry*

Substances

Amines
Urea
Monophenol Monooxygenase