Post-transcriptional regulation of loss of rat striatal D2 dopamine receptor during aging

Brain Res. 1992 Mar 20;575(2):309-14. doi: 10.1016/0006-8993(92)90095-q.

Abstract

The mechanism(s) underlying age-associated diminutions in the rat striatal D2 dopamine receptor (D2-receptor) number was investigated. The levels of D2-receptor mRNA in 4-, 12- and 18-month-old rat striata were found not to change. In contrast, the levels of 110 kDa protein, labeled with a D2-receptor specific antibody, decreased in parallel with [3H]YM-09151-2 binding to striatal membranes. These data suggest a role for post-transcriptional mechanism(s) in age-associated decrease in D2-receptor.

MeSH terms

  • Actins / genetics
  • Aging / metabolism*
  • Animals
  • Base Sequence
  • Benzamides / metabolism
  • Corpus Striatum / metabolism*
  • Male
  • Molecular Sequence Data
  • RNA Processing, Post-Transcriptional
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Inbred F344
  • Receptors, Dopamine / genetics
  • Receptors, Dopamine / metabolism*
  • Receptors, Dopamine D2

Substances

  • Actins
  • Benzamides
  • RNA, Messenger
  • Receptors, Dopamine
  • Receptors, Dopamine D2
  • nemonapride