Repeatability of noninvasive surrogates of endothelial function

Jan Malik; Dan Wichterle; Tomas Haas; Vojtech Melenovsky; Jan Simek; Tomas Stulc

doi:10.1016/j.amjcard.2004.05.049

Repeatability of noninvasive surrogates of endothelial function

Am J Cardiol. 2004 Sep 1;94(5):693-6. doi: 10.1016/j.amjcard.2004.05.049.

Authors

Jan Malik¹, Dan Wichterle, Tomas Haas, Vojtech Melenovsky, Jan Simek, Tomas Stulc

Affiliation

¹ Third Department of Medicine, General University Hospital, Prague, Czech Republic. jmali@lf1.cuni.cz

PMID: 15342316
DOI: 10.1016/j.amjcard.2004.05.049

Abstract

We compared the repeatability of 2 ultrasonographic methods for endothelial function assessment at brachial artery-flow-mediated dilation (FMD) and post-ischemic peak blood flow (PBF). Twenty healthy volunteers were examined twice within 10 days; coefficients of variation were 13.8% for PBF and 41.0% for FMD. PBF seems to be superior to FMD in terms of reproducibility. Consequently, smaller noninvasive studies of endothelial function can be designed utilizing PBF compared with FMD.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Blood Flow Velocity / physiology
Brachial Artery / physiopathology
Endothelium, Vascular / diagnostic imaging*
Endothelium, Vascular / physiopathology
Humans
Male
Reproducibility of Results
Ultrasonography / methods*
Vasodilation / physiology