Understanding social contextual mediators of risk in HIV/AIDS prevention and promoting cultural adaptation of clinical interventions have evolved from new priorities set forth by the National Institutes of Health (NIH) on ecological validity and translational research (NIH, 2001). Thus, emphasis is placed on linguistically and culturally translating promising interventions "for and with" new populations to serve the realities of the particular group. The purpose of this paper is to describe the process involved in developing culturally sensitive interventions to strengthen the ecological validity of a cognitive behavioral stress management (CBSM) intervention for HIV+ individuals.