The structure of an endosomal protein sorter

Dev Cell. 2004 Oct;7(4):457-8. doi: 10.1016/j.devcel.2004.09.007.

Abstract

Three "endosomal sorting complexes required for transport," ESCRT-I, -II, and -III, mediate sorting of ubiquitinated membrane proteins into intraluminal endosomal vesicles that are destined for degradation in lysosomes. Two recent reports, one in Nature and one in this issue of Developmental Cell, reveal the crystal structure of the yeast form of ESCRT-II.

Publication types

  • Comment

MeSH terms

  • Amino Acid Sequence
  • Carrier Proteins / chemistry
  • Carrier Proteins / metabolism
  • Crystallography, X-Ray
  • Dimerization
  • Endosomal Sorting Complexes Required for Transport
  • Endosomes / chemistry*
  • Endosomes / metabolism
  • Liposomes / metabolism
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism*
  • Membranes / metabolism
  • Models, Molecular
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Protein Transport / physiology*
  • Saccharomyces cerevisiae / chemistry
  • Saccharomyces cerevisiae Proteins / chemistry
  • Saccharomyces cerevisiae Proteins / metabolism
  • Ubiquitin / metabolism
  • Ubiquitins / metabolism
  • Vesicular Transport Proteins
  • Zinc Fingers

Substances

  • Carrier Proteins
  • Endosomal Sorting Complexes Required for Transport
  • Liposomes
  • Membrane Proteins
  • SNF8 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Ubiquitin
  • Ubiquitins
  • Vesicular Transport Proteins
  • Vps25 protein, S cerevisiae
  • Vps36 protein, S cerevisiae