False-positive Aspergillus galactomannan enzyme-linked immunosorbent assay results in vivo during amoxicillin-clavulanic acid treatment

J Clin Microbiol. 2004 Nov;42(11):5362-3. doi: 10.1128/JCM.42.11.5362-5363.2004.

Abstract

Positive Platelia Aspergillus test results were observed in consecutive serum samples from an immunocompromised host during amoxicillin-clavulanic acid treatment, and a correlation between plasmatic amoxicillin concentration and galactomannan optical density index was observed. Amoxicillin-clavulanic acid vials tested positive for galactomannan but were negative for Aspergillus DNA.

MeSH terms

  • Amoxicillin-Potassium Clavulanate Combination / therapeutic use*
  • Aspergillosis / diagnosis*
  • Aspergillosis / drug therapy*
  • Aspergillus / isolation & purification
  • Enzyme-Linked Immunosorbent Assay
  • False Positive Reactions
  • Female
  • Galactose / analogs & derivatives
  • Humans
  • Immunocompromised Host
  • Mannans / analysis*
  • Middle Aged
  • Reagent Kits, Diagnostic*

Substances

  • Mannans
  • Reagent Kits, Diagnostic
  • galactomannan
  • Amoxicillin-Potassium Clavulanate Combination
  • Galactose