Causes of death in HIV infection: the key determinant to define the clinical response to anti-HIV therapy

AIDS. 2004 Nov 19;18(17):2333-7. doi: 10.1097/00002030-200411190-00018.

Abstract

Studies have shown an increased risk of new AIDS/death among injecting drug users (IDU) starting highly active antiretroviral therapy (HAART). Of 3872 patients starting HAART in the EuroSIDA study, 819 were IDU (21.2%). During 14 769 person-years of follow-up, 499 patients progressed to new AIDS/death. Compared with homosexual individuals, IDU had an increased incidence of new AIDS/death, but only for non-HIV deaths. There is an urgent need to define and standardize causes of death in observational studies.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications
  • Acquired Immunodeficiency Syndrome / drug therapy
  • Acquired Immunodeficiency Syndrome / mortality
  • Antiretroviral Therapy, Highly Active / methods*
  • Cohort Studies
  • Disease Progression
  • HIV Infections / complications
  • HIV Infections / drug therapy
  • HIV Infections / mortality*
  • HIV Protease Inhibitors / therapeutic use
  • Homosexuality
  • Humans
  • Reverse Transcriptase Inhibitors / therapeutic use
  • Substance Abuse, Intravenous / complications
  • Substance Abuse, Intravenous / mortality*

Substances

  • HIV Protease Inhibitors
  • Reverse Transcriptase Inhibitors